We welcome candidate variant submissions which will allow this resource to be more comprehensive and
useful to the community at large. If you have a submission please fill out a variant submission form.
If you would like to contribute your curation efforts to DoCM please contact us.
How is DoCM different from COSMIC, TCGA, ICGC and ClinVar?
DoCM captures variants with known biological or clinical relevance, supported by the literature, requiring
more than simply an observation or occurance in a cancer sample as with COSMIC, TCGA and ICGC. While
ClinVar's scope is focused on linking variation to phenotype with supporting evidence, DoCM focuses on
linking variants to biologically functional or clinically relevant variation as outlined in the literature.
Is the DoCM web client open source?
Yes! DoCM is released under the MIT License
and you can find the code on GitHub. Send us a pull request,
we would love to review your code and incorporate features from the community.
How do I use the DoCM API?
The API can be queried using HTTP requests. More information can be
found at our API Documentation page.
How often is DoCM updated?
DoCM is updated as new curated lists and variants are brought
to our attention. If you think we are missing a variant or need to
update a record, please submit your query.
How do I download DoCM variants?
You can download variants via the API, or you can
use the TSV or VCF buttons on the main page. These will be filtered
according to the criteria that you specify (i.e. chromosome, disease, etc) in the left sidebar.
The TSV button will download a tab separated values file. The VCF button will
download a variant call format file.
How is versioning handled in DoCM?
The DoCM web interface API features a comprehensive versioning system that allows users view and download
previous versions of the database. By default the web client displays the current version of the database;
to access a prior version of the database with the web client select your desired version from the 'version'
field on the left sidebar. To download a prior version using the API use version parameter.
See the API documentation for more information.
What is the difference between major and minor versions in DoCM?
Minor versions were introduced with the automatic CIViC
importer. A minor version update indicates another update of DoCM with CIViC variants. A major version
update indicate the addition of variants from a new set of publications curated into DoCM.
How are transcripts selected in DoCM?
Transcripts are selected by individual curators and should most accurately capture the variant
outlined in the referenced publication. In the event that multiple suitable transcripts are present curator
should filter the transcripts by some criteria, like the pathogenicity or length of the transcript. Curators
should outline their transcript selection strategy in the rationale statement for their batch.